| Contents |
Drug-receptor interactions / Rob Leurs -- An introduction to ion channels / Brian Cox -- Intercellular targets / Eric Hunt ... [et al.] -- Enzyme inhibitors / David A. Roberts and Walter H.J. Ward -- Biological evaluation of novel compounds / Gary W. Price, Graham J. Riley and Derek N. Middlemiss -- Pharmacokinetics / Phillip Jeffrey -- Drug metabolism / Stephen E. Clarke -- Toxicology in the drug discovery process / Susan M. Evans, Elisabeth George and C. Westmoreland -- Chemical development / Paul Smith -- Physicochemical properties / Han van de Waterbeemd -- Quantitative structure |
| Contents |
: activity relationships / David J. Livingstone -- Computational chemistry and target structure / Colin Edge -- Patent medicine / Bill Tyrrell -- An introduction to molecular biology / Ralph Rapley and Robert J. Slater -- Strategy and tactics in drug discovery / Frank D. King -- Combinatorial chemistry : tools for the medicinal chemist / Morag A.M. Easson and David C. Rees -- The identification of selective 5-HT2c receptor antagonists : a new approach to the treatment of depression and anxiety / Steven M. Bromidge -- The identification of the HIV protease inhibitor |
| Contents |
saquinavir / Frank D. King -- Discovery of vioxx (rofecoxib) / Frank D. King -- NK1 receptor antagonists / Chris Swain. |
| Bibliography note | Includes bibliographical references and index. |
| LCCN | 2005472326 |
| ISBN | 0854046313 |
| ISBN | 9780854046317 |
