| Summary |
The purpose of this study was to determine if 7 days of endurance exercise would elicit positive changes in insulin action, insulin receptor tyrosine kinase (IRTK) activity and membrane glycoprotein PC-1 between sedentary lean and obese participants. The average age of all participants was 28.6 ±1.2 years. Ten sedentary lean subjects (average BMI of 24.0 ± 0.8 kg/m ) and ten sedentary obese subjects (average BMI of 32.1 ± 0.9 kg/m2) participated in the study. Measurements included: seven-site skinfold testing for body composition, cycle ergometer V02max test, minimal model procedure and a biopsy of the vastus lateralis. Participants then exercised for seven consecutive days on a cycle ergometer at 70-75% of VC^max. Post-testing occurred within 12-15 hours after the last day of exercise. Muscle samples were analyzed at the University of California San Francisco (UCSF) for analysis of IRTK and PC-1. Results are reported in terms of lean, obese and a combined ALL group. Differences were seen between the lean and obese groups in terms of fasting insulin and Homeostasis Model Assessment (HOMA) but not in terms of a training effect. However, SI and insulin receptor tyrosine kinase activity increased with training regardless of body composition. Even though there were no interactions between the lean and obese, there were significant training effects on the group as a whole (ALL). These results support the hypotheses that an increase in insulin receptor tyrosine kinase of the vastus lateralis would occur after 7 days of endurance training and exercise would significantly improve insulin action in both the lean and obese groups. However, these results do not support the hypothesis that PC-1 would decrease with training. More human research is needed to determine the effect/interactions PC-1 may have on the insulin receptor. |
| General note | Presented to the faculty of the Department of Exercise and Sport Science. |
| General note | Advisor: Joseph A. Houmard |
| Dissertation note | M.A. East Carolina University 2004 |
| Bibliography note | Includes bibliographical references (leaves 48-53). |
| Genre/form | doctoral dissertations. |
| Genre/form | masters theses. |
| Genre/form | dissertations. |
| Genre/form | theses. |
| Genre/form | Academic theses. |
| Genre/form | Academic theses. |
| Genre/form | Thèses et écrits académiques. |
