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LEADER 08931cam 2200805Ii 4500
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a| Osteoporosis /
c| edited by Robert Marcus, David Feldman, David W. Dempster, Marjorie Luckey, Jane A. Cauley.
250
a| Fourth edition.
264
1
a| Amsterdam :
b| Elsevier/Academic Press,
c| 2013.
300
a| 1 online resource (2 volumes (xxv, 1,995 pages, 18 unnumbered pages of plates)) :
b| illustrations (chiefly color).
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a| ClinicalKey
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a| Previous edition: 2008.
504
a| Includes bibliographical references and index.
505
0
a| V: 1 -- The bone organ system: form and function -- The nature of osteoporosis -- Reflections on osteoporosis -- Reflections on development of concepts of intercellular communication in bone -- Osteo-odyssey: a memoir -- Development of the skeleton -- The skeletal stem cell -- Osteoclast biology -- Osteoblast biology -- Osteocyte biology -- The regulatory role of matrix protein in mineralization of bone -- Parathyroid hormone and parathyroid hormone-related protein -- Vitamin D: biology, actions, and clinical implications -- Regulation of bone cell function by estrogens -- Androgens and skeletal biology: basic mechanisms -- Phosphatonins -- Skeletal growth factors -- Wnt signaling in skeletal homeostasis and diseases -- The mechanical behavior of bone -- Cellular and molecular mechanotransduction in bone -- Adaptation of skeletal structure to mechanical loading -- Biomechanics of hip and vertebral fractures -- Prevention of osteoporosis by physical signals: defining a potential role for nondrug strategies in the treatment of musculoskeletal injury and disease -- Epidemiologic methods in studies of osteoporosis -- Genetic determinants of osteoporosis -- Race, ethnicity, and osteoporosis -- Geographic variability in hip and vertebral fractures -- Nutrition and risk for osteoporosis -- Physical activity and exercise in the maintenance of the adult skeleton and the prevention of osteoporotic fractures -- Premenopausal reproductive and hormonal characteristics and the risk for osteoporosis -- Clinical and epidemiological studies: skeletal changes across menopause -- Osteoporosis in men: epidemiology, pathophysiology, and clinical characterization -- Falls as risk factors for fracture -- Nonskeletal risk factors for osteoporosis and fractures -- Outcomes following osteoporotic fractures -- Skeletal heterogeneity and the purposes of bone remodeling: implications for the understanding of osteoporosis -- On the evolution and contemporary roles of bone remodeling -- Cytokines and the pathogenesis of osteoporosis -- Animal models for osteoporosis -- Bone and fat -- Bone mineral acquisition in utero and during infancy and childhood -- Bone acquisition in adolescence.
505
0
a| V: 2 -- Osteoporosis in childhood and adolescence -- Osteoporosis associated with pregnancy -- Osteoporosis in premenopausal women -- Estrogen deficiency, postmenopausal osteoporosis, and age-related bone loss -- Immobilization osteoporosis -- Osteoporosis associated with illnesses and medications -- Glucocorticoid-induced osteoporosis -- Anticonvulsant-related bone disease -- Thyroid hormone and the skeleton -- The skeletal actions of parathyroid hormone in primary hyperparathyroidism and in osteoporosis -- Osteogenesis imperfecta and other defects of bone development as occasional causes of adult osteoporosis -- HIV and osteoporosis -- Obesity, diabetes, and fractures -- Osteoporosis in organ transplant patients -- Osteoporosis associated with rheumatologic disorders -- Osteoporosis associated with chronic kidney disease -- Oral bone loss and systemic osteoporosis: weighing the risk benefit ratio of treatment -- Cancer treatment-induced bone loss in patients with breast cancer: pathophysiology and clinical perspectives -- Pathophysiology-prostate cancer -- Mechanisms of bone destruction in myeloma -- Evaluation of the patient at risk for osteoporosis -- Imaging of osteoporosis -- Osteoporosis: who should be treated? Who should be screened? -- Clinical use of bone densitometry -- Biochemical markers of bone turnover in osteoporosis -- Fracture risk assessment: the development and application of FRAX® -- Orthopedic aspects of osteoporosis -- Falls prevention interventions -- Physical therapy, physical modalities, and exercise regimens in the management of osteoporosis -- Calcium in the treatment of osteoporosis -- Vitamin D and its metabolities and analogs in the management of osteoporosis -- Alternative therapy through nutrients and nutraceuticals -- Design considerations for clinical investigations of osteoporosis -- Lessons from bone histomorphometry on the mechanisms of action of osteoporosis drugs -- Estrogen and estrogen analogs for prevention and treatment of osteoporosis -- Androgens -- Calcitonin in osteoporosis -- Bisphosphonates: pharmacology and use in the treatment of osteoporosis -- Osteonecrosis of the jaw and atypical femoral fractures -- Condition critical: compliance and persistence with osteoporosis medications -- Denosumab for the treatment of osteoporosis -- Strontium ranelate in the prevention of osteoporotic fractures -- Parathyroid hormone treatment for osteoporosis -- New approaches to osteoporosis therapeutics -- The past, present, and uncertain future of therapeutic innovation in osteoporosis.
588
0
a| Print version record.
520
a| Now in its third edition, Osteoporosis, is the most comprehensive, authoritative reference on this disease. Written by renowned experts in the field, this two-volume reference is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. Worldwide, 200 million women between 60-80 suffer from osteoporosis and have a lifetime risk of fracture between 30 and 40 % continuing to make osteoporosis a hot topic in medicine.
546
a| English.
650
0
a| Osteoporosis.
=| ^A5421
650
2
2
a| Osteoporosis
x| therapy.
=| ^A923735
650
2
a| Fractures, Bone
x| pathology.
=| ^A1167619
650
2
a| Osteoporosis.
=| ^A919340
650
2
a| Osteporosis
x| therapy.
?| UNAUTHORIZED
655
0
a| Osteoporosis.
=| ^A5421
700
1
a| Marcus, Robert,
d| 1940-
e| editor.
=| ^A1158596
700
1
a| Feldman, David,
d| 1939-
e| editor.
=| ^A957913
700
1
a| Dempster, David W.,
e| editor.
=| ^A930976
700
1
a| Luckey, Marjorie,
e| editor.
=| ^A1321840
700
1
a| Cauley, Jane A.,
e| editor.
=| ^A1320446
776
0
8
i| Print version:
t| Osteoporosis.
b| Fourth edition.
d| Amsterdam : Elsevier/Academic Press, 2013
z| 9780124158535
w| (OCoLC)839312872
830
0
a| ClinicalKey.
?| UNAUTHORIZED
856
4
0
u| https://ebookcentral.proquest.com/lib/eastcarolina/detail.action?docID=1215501
z| Direct link to resource
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